團(tuán)隊(duì)人員

1.   研究組長：侯陵研究員，博士，研究員，博士生導(dǎo)師。曾師從發(fā)育生物學(xué)教授劉筠院士并獲碩士學(xué)位。留學(xué)日本Tohoku大學(xué)并獲博士學(xué)位，后赴美國印第安納大學(xué)醫(yī)學(xué)院從事博士后，并先后在美國國立衛(wèi)生研究院(NIH)任助理研究員，副研究員，Scientist。2008年作為海外高層次人才引進(jìn)溫州醫(yī)科大學(xué)，任眼視光學(xué)與視覺科學(xué)國家重點(diǎn)實(shí)驗(yàn)室研究員，浙江省模式生物技術(shù)與應(yīng)用重點(diǎn)實(shí)驗(yàn)室副主任。現(xiàn)為國家重點(diǎn)研發(fā)計(jì)劃評(píng)審專家、國家自然科學(xué)基金重大研究計(jì)劃和面上項(xiàng)目評(píng)議專家，浙江省自然基金委評(píng)審專家、中國遺傳咨詢網(wǎng)專家委員會(huì)成員, PLOS One的編委，The American Journal of Human Genetics, Stem Cells, Journal of Investigative Dermatology, Pigment Cell & Melanoma Research, Journal of Dermatological Science, Journal of Photochemistry & Photobiology, Experimental Dermatology, Mechanisms of Development, PLOS One, Journal of Cellular and Molecular Medicine, Differentiation等學(xué)術(shù)期刊評(píng)委。

2.   工作人員：陳瑜、麻曉銀、蘇中淵、李輝榮、王靚

研究方向

視網(wǎng)膜色素上皮細(xì)胞生物學(xué)與視網(wǎng)膜退行性病變

視網(wǎng)膜退行性病變是世界范圍內(nèi)主要的致盲性眼病，目前尚無有效的治療方法，其重要原因之一是該類疾病的發(fā)生發(fā)展的分子機(jī)制尚未完全闡明。本團(tuán)隊(duì)的研究興趣之一是視網(wǎng)膜發(fā)育及功能障礙中的轉(zhuǎn)錄調(diào)控及信號(hào)通路。我們通過利用先天性視網(wǎng)膜變性，年齡相關(guān)視網(wǎng)膜病變及氧化應(yīng)激誘導(dǎo)的視網(wǎng)膜變性小鼠模型，結(jié)合細(xì)胞生物學(xué)技術(shù)、分子生物學(xué)技術(shù)，Chip-seq，RNA-seq高通量篩選等技術(shù)，以闡明特異性視網(wǎng)膜變性的分子和細(xì)胞機(jī)理。在此基礎(chǔ)上，我們將對(duì)小鼠采用基因療法或藥物治療，以期望找到可有效減慢或延緩視網(wǎng)膜退行性病變的有效治療方式。

Laboratory of Developmental Cell Biology and Disease

Team Members

1.    Principal investigator: Ling Hou, MD, PhD

Dr. Ling Hou received his Ph.D. in 1992 from Tohoku University, Japan, where he worked with Takuji Takeuchi. From 1992 to 1996, he did postdoctoral training at the Indiana University School of Medicine, USA. From 1997 to 2000, he worked as a Research Associate Scientist with Heinz Arnheiter at NIH, USA. From 2000 to 2007, he was a Senior Research Fellow and then a Staff Scientist at NHGRI, NIH in USA. Now he works as a Senior Investigator of Cell Biology, and Molecular Genetic and Developmental Genetic Ophthalmology at State Key Laboratory of Ophthalmology, Optometry and Vision Science in China, where his program continually investigates the molecular and cellular mechanisms underlying RPE cell & melanocyte biology and retinal degeneration.

2.   Team Staff：Yu Chen，Xiaoyin Ma, Zhongyuan Su，Huirong Li，Jing Wang

Scope of Research Proposal

Retinal Pigment Epithelial Cell Biology and Retinal Degeneration

Retinal degeneration is the leading cause of blindness in the world, which still lacks effective treatments. One of the reasons is the molecular mechanisms of the retinal degeneration have not been fully understood. Our research interest is the transcriptional regulation and signaling pathways in retinal development and dysfunctions. We use the congenital retinal degeneration, age-related retinal degeneration, and stress induced retinal generation mice models, combined with cellular biology, molecular biology and high throughput assays, such as ChIP-seq, RNA-seq to elucidate the molecular and cellular mechanisms of the specific retinal degeneration. Based on the elucidated mechanisms, we will use the gene therapy or drug treatment to treat the mice, we hope we can find effective ways to delay or slow down the retinal degeneration.