團(tuán)隊(duì)人員

1.  研究組長：閆東升，博士，研究員。1993年至 1998年在白求恩醫(yī)科大學(xué)臨床醫(yī)學(xué)系完成本科學(xué)習(xí)，之后赴吉林大學(xué)生化與分子生物學(xué)系開始碩士學(xué)習(xí)，2001年至2006年中科院遺傳與發(fā)育生物學(xué)研究所攻讀博士。2006年加入溫州醫(yī)科大學(xué)組建實(shí)驗(yàn)室。

2.  團(tuán)隊(duì)成員：陳曉燕、陳偉偉、王教、王麗花、曹瓊潔、林永、葉菊秀

研究方向

 本課題組的研究興趣是眼發(fā)育和疾病過程中的表觀遺傳機(jī)制。表觀遺傳學(xué)已成為當(dāng)前的研究熱點(diǎn)，對(duì)眼部疾病的表觀遺傳機(jī)制研究將為其治療提供新的策略，特別是對(duì)于目前尚缺乏有效治療手段的致盲性眼部疾病，闡明其分子機(jī)制極為重要。表觀遺傳調(diào)控包括DNA甲基化，組蛋白修飾和非編碼RNA。表觀遺傳修飾廣泛見于各種生理和病理過程，闡明這些修飾在眼部疾病中的改變與功能具有極為重要的意義。目前，我們重點(diǎn)研究非編碼RNA在葡萄膜黑色素瘤以及糖尿病視網(wǎng)膜病變等眼部疾病中的功能與分子機(jī)制，研究成果將為這些疾病的治療提供新的思路。

Laboratory of Ocular Epigenetics

Team Members

1.         Principal Investigator: Dongsheng Yan, M.D., Ph.D.

From 1993 to 1998, He obtained his bachelor degree in Department of Clinical Medicine, Norman Bethune Medical. Then he went to Jilin University for his mater study in Biochemistry. He finished his PhD study in Institute of Genetics and Developmental Biology. In 2006, he went to Wenzhou Medical University and established his own lab.                          

2.         Team Staff: Xiaoyan Chen, Weiwei Chen, Jiao Wang, Lihua Wang, Qiongjie Cao, Yong Lin, Juxiu Ye

Scope of Research Proposal

  Dr. Dongsheng Yan's laboratory is interested in studying epigenetic mechanism in eye development and disease. Epigenetics is a topic of heightening interest in ophthalmology because of its translational potential to develop novel strategies for improving treatment of anterior and posterior segment ocular diseases. This approach is of critical importance because currently in many cases the approaches in vogue only provide palliative relief without affecting the underlying mechanisms of sight compromising pathology. Epigenetic regulation entails DNA methylation, histone modifications and non-coding RNAs. As epigenetic modifications are implicated in an ever increasing number of physiological and pathological processes, there is a burgeoning interest to identify associations between aberrant changes and dysfunctional responses underlying different ocular diseases. Specially, it is of great interest to us to realize the specific associations between non-coding RNAs and their numerous targets that are perturbed in blinding eye diseases such as uveal melanoma and diabetic retinopathy. Such insights will be helpful for developing novel strategies in order to establish effective treatments of ocular diseases and thereby reverse losses in visual acuity.